Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial.
Identifieur interne : 000F82 ( Main/Exploration ); précédent : 000F81; suivant : 000F83Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial.
Auteurs : Robert P. Giugliano [États-Unis] ; Terje R. Pedersen [Norvège] ; Jeong-Gun Park [États-Unis] ; Gaetano M. De Ferrari [Italie] ; Zbigniew A. Gaciong [Pologne] ; Richard Ceska [République tchèque] ; Kalman Toth [Hongrie] ; Ioanna Gouni-Berthold [Allemagne] ; Jose Lopez-Miranda [Espagne] ; François Schiele [France] ; François Mach [Suisse] ; Brian R. Ott [États-Unis] ; Estella Kanevsky [États-Unis] ; Armando Lira Pineda [États-Unis] ; Ransi Somaratne [États-Unis] ; Scott M. Wasserman [États-Unis] ; Anthony C. Keech [Australie] ; Peter S. Sever [Royaume-Uni] ; Marc S. Sabatine [États-Unis]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
LDL cholesterol is a well established risk factor for atherosclerotic cardiovascular disease. How much one should or safely can lower this risk factor remains debated. We aimed to explore the relationship between progressively lower LDL-cholesterol concentrations achieved at 4 weeks and clinical efficacy and safety in the FOURIER trial of evolocumab, a monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9).
DOI: 10.1016/S0140-6736(17)32290-0
PubMed: 28859947
Affiliations:
- Allemagne, Australie, Espagne, France, Hongrie, Italie, Norvège, Pologne, Royaume-Uni, République tchèque, Suisse, États-Unis
- Angleterre, Bohême centrale, Bourgogne-Franche-Comté, Californie, Franche-Comté, Grand Londres, Massachusetts, Nouvelle-Galles du Sud, Rhode Island, Østlandet
- Besançon, Londres, Oslo, Prague, Sydney
- Université de Sydney
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Giugliano</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: rgiugliano@bwh.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name><affiliation wicri:level="3"><nlm:affiliation>Oslo University Hospital, Ullevål and Medical Faculty, University of Oslo, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Oslo University Hospital, Ullevål and Medical Faculty, University of Oslo, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Park, Jeong Gun" sort="Park, Jeong Gun" uniqKey="Park J" first="Jeong-Gun" last="Park">Jeong-Gun Park</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="De Ferrari, Gaetano M" sort="De Ferrari, Gaetano M" uniqKey="De Ferrari G" first="Gaetano M" last="De Ferrari">Gaetano M. De Ferrari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine, University of Pavia and Cardiac Intensive Care Unit and Laboratories for Experimental Cardiology, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Molecular Medicine, University of Pavia and Cardiac Intensive Care Unit and Laboratories for Experimental Cardiology, IRCCS Fondazione Policlinico San Matteo, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Gaciong, Zbigniew A" sort="Gaciong, Zbigniew A" uniqKey="Gaciong Z" first="Zbigniew A" last="Gaciong">Zbigniew A. Gaciong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hypertension and Vascular Diseases, The Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Internal Medicine, Hypertension and Vascular Diseases, The Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Ceska, Richard" sort="Ceska, Richard" uniqKey="Ceska R" first="Richard" last="Ceska">Richard Ceska</name><affiliation wicri:level="3"><nlm:affiliation>Center of Preventive Cardiology, 3rd Department Internal Medicine, University General Hospital and 1st Medical Faculty, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Center of Preventive Cardiology, 3rd Department Internal Medicine, University General Hospital and 1st Medical Faculty, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Toth, Kalman" sort="Toth, Kalman" uniqKey="Toth K" first="Kalman" last="Toth">Kalman Toth</name><affiliation wicri:level="1"><nlm:affiliation>1st Department of Medicine, University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>1st Department of Medicine, University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Gouni Berthold, Ioanna" sort="Gouni Berthold, Ioanna" uniqKey="Gouni Berthold I" first="Ioanna" last="Gouni-Berthold">Ioanna Gouni-Berthold</name><affiliation wicri:level="1"><nlm:affiliation>Polyclinic for Endocrinology, Diabetes, and Preventive Medicine, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Polyclinic for Endocrinology, Diabetes, and Preventive Medicine, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Miranda, Jose" sort="Lopez Miranda, Jose" uniqKey="Lopez Miranda J" first="Jose" last="Lopez-Miranda">Jose Lopez-Miranda</name><affiliation wicri:level="1"><nlm:affiliation>Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University Hospital, University of Cordoba, CIBEROBN, Cordoba, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Lipids and Atherosclerosis Unit, Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University Hospital, University of Cordoba, CIBEROBN, Cordoba</wicri:regionArea><wicri:noRegion>Cordoba</wicri:noRegion></affiliation></author><author><name sortKey="Schiele, Francois" sort="Schiele, Francois" uniqKey="Schiele F" first="François" last="Schiele">François Schiele</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Center Besançon, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Hospital Center Besançon, Besançon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Mach, Francois" sort="Mach, Francois" uniqKey="Mach F" first="François" last="Mach">François Mach</name><affiliation wicri:level="1"><nlm:affiliation>Hopital Cantonal, Hopitaux Universitaires de Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Hopital Cantonal, Hopitaux Universitaires de Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Ott, Brian R" sort="Ott, Brian R" uniqKey="Ott B" first="Brian R" last="Ott">Brian R. Ott</name><affiliation wicri:level="2"><nlm:affiliation>Rhode Island Hospital, Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rhode Island Hospital, Department of Neurology, Alpert Medical School of Brown University, Providence, RI</wicri:regionArea><placeName><region type="state">Rhode Island</region></placeName></affiliation></author><author><name sortKey="Kanevsky, Estella" sort="Kanevsky, Estella" uniqKey="Kanevsky E" first="Estella" last="Kanevsky">Estella Kanevsky</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pineda, Armando Lira" sort="Pineda, Armando Lira" uniqKey="Pineda A" first="Armando Lira" last="Pineda">Armando Lira Pineda</name><affiliation wicri:level="2"><nlm:affiliation>Amgen, Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen, Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Somaratne, Ransi" sort="Somaratne, Ransi" uniqKey="Somaratne R" first="Ransi" last="Somaratne">Ransi Somaratne</name><affiliation wicri:level="2"><nlm:affiliation>Amgen, Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen, Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wasserman, Scott M" sort="Wasserman, Scott M" uniqKey="Wasserman S" first="Scott M" last="Wasserman">Scott M. Wasserman</name><affiliation wicri:level="2"><nlm:affiliation>Amgen, Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Amgen, Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name><affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name><affiliation wicri:level="3"><nlm:affiliation>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">LDL cholesterol is a well established risk factor for atherosclerotic cardiovascular disease. How much one should or safely can lower this risk factor remains debated. We aimed to explore the relationship between progressively lower LDL-cholesterol concentrations achieved at 4 weeks and clinical efficacy and safety in the FOURIER trial of evolocumab, a monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9).</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Italie</li><li>Norvège</li><li>Pologne</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bohême centrale</li><li>Bourgogne-Franche-Comté</li><li>Californie</li><li>Franche-Comté</li><li>Grand Londres</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Rhode Island</li><li>Østlandet</li></region><settlement><li>Besançon</li><li>Londres</li><li>Oslo</li><li>Prague</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Giugliano, Robert P" sort="Giugliano, Robert P" uniqKey="Giugliano R" first="Robert P" last="Giugliano">Robert P. Giugliano</name></region><name sortKey="Kanevsky, Estella" sort="Kanevsky, Estella" uniqKey="Kanevsky E" first="Estella" last="Kanevsky">Estella Kanevsky</name><name sortKey="Ott, Brian R" sort="Ott, Brian R" uniqKey="Ott B" first="Brian R" last="Ott">Brian R. Ott</name><name sortKey="Park, Jeong Gun" sort="Park, Jeong Gun" uniqKey="Park J" first="Jeong-Gun" last="Park">Jeong-Gun Park</name><name sortKey="Pineda, Armando Lira" sort="Pineda, Armando Lira" uniqKey="Pineda A" first="Armando Lira" last="Pineda">Armando Lira Pineda</name><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name><name sortKey="Somaratne, Ransi" sort="Somaratne, Ransi" uniqKey="Somaratne R" first="Ransi" last="Somaratne">Ransi Somaratne</name><name sortKey="Wasserman, Scott M" sort="Wasserman, Scott M" uniqKey="Wasserman S" first="Scott M" last="Wasserman">Scott M. Wasserman</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name></region></country><country name="Italie"><noRegion><name sortKey="De Ferrari, Gaetano M" sort="De Ferrari, Gaetano M" uniqKey="De Ferrari G" first="Gaetano M" last="De Ferrari">Gaetano M. De Ferrari</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Gaciong, Zbigniew A" sort="Gaciong, Zbigniew A" uniqKey="Gaciong Z" first="Zbigniew A" last="Gaciong">Zbigniew A. Gaciong</name></noRegion></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Ceska, Richard" sort="Ceska, Richard" uniqKey="Ceska R" first="Richard" last="Ceska">Richard Ceska</name></region></country><country name="Hongrie"><noRegion><name sortKey="Toth, Kalman" sort="Toth, Kalman" uniqKey="Toth K" first="Kalman" last="Toth">Kalman Toth</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Gouni Berthold, Ioanna" sort="Gouni Berthold, Ioanna" uniqKey="Gouni Berthold I" first="Ioanna" last="Gouni-Berthold">Ioanna Gouni-Berthold</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Lopez Miranda, Jose" sort="Lopez Miranda, Jose" uniqKey="Lopez Miranda J" first="Jose" last="Lopez-Miranda">Jose Lopez-Miranda</name></noRegion></country><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Schiele, Francois" sort="Schiele, Francois" uniqKey="Schiele F" first="François" last="Schiele">François Schiele</name></region></country><country name="Suisse"><noRegion><name sortKey="Mach, Francois" sort="Mach, Francois" uniqKey="Mach F" first="François" last="Mach">François Mach</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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